Prospects of osteosynthesis with fixators based on magnesium alloys, mechanical and physiological properties. The state of the problem at the current stage.

Setting the objective: The aim of this work is to analyze the available scientific information regarding to the prospects of metal-osteosynthesis with biodegradable fixators based on magnesium alloys. Materials and methods: A set of general and special methods of scientific knowledge are used in the article.Search and analysis of full-text articles and scientific publications - carried out in databases of systematic reviews of MEDLINE, PubMed, Web of Science, Google Scholar, Scopus. Results: The use of fixators made of magnesium alloys during osteosynthesis of bone fractures does not require the second surgical intervention with regard to remove the fixators, which have fulfilled their goal. Magnesium alloys are light and have one-third the density of titanium fasteners. No pressure is created at the place of implantation, due to the fact that the Young's modulus of implants is similar to the modulus of bone tissue. Magnesium-based implants contribute to osteogenesis, angiogenesis, neuroregeneration, regeneration and remodeling of bones at the same time inhibiting osteoclast activity and inflammation. Magnesium and its alloys have excellent biocompatibility with bone tissue. Conclusions: Magnesium-based implants contribute to a tissue regeneration and healing during degradation and do not require removal. This allows you to avoid the second surgical intervention and reduces treatment costs. That is why the development and implementation of biodegradable fixators for osteosynthesis is of great importance.