A many‐objective optimization‐based local tensor factorization model for skin cancer detection

Summary Exploring the associations between microRNAs (miRNAs) and diseases can identify potential disease features. Prediction of miRNA‐skin cancer associations has become an effective method for detecting skin cancer, as direct detection of skin cancer is challenging. However, traditional binary associations prediction methods overlook high‐order feature differences of miRNAs in different types of skin cancer. Although current tensor decomposition methods have addressed this, they assume a consistent composition standard of global tensor elements, ignoring differences in the composition standards of local sub‐tensors. This leads to poor prediction accuracy and comprehensiveness and fails to consider the credibility and diversity requirements of patients and doctors in practical applications. In this paper, we represent miRNA‐skin cancer associations as a tensor and employ tensor decomposition for tensor completion to achieve prediction purposes. First, we propose a credibility evaluation indicator and introduce four objective functions: accuracy, comprehensiveness, credibility, and diversity, to construct a many‐objective local tensor factorization model (MOLTF). Then, to avoid wrong individuals when solving this model with genetic algorithms, we propose a corrected single‐point crossover operator and a corrected multi‐point mutation operator. On the miRNA‐disease dataset HMDD v3.2, our algorithm improves accuracy by 14.5% compared to the recent baseline, demonstrating its effectiveness.