化学
酶
组合化学
催化作用
酶催化
活动站点
功能群
蛋白质工程
范围(计算机科学)
立体化学
有机化学
计算机科学
程序设计语言
聚合物
作者
Dibyendu Mondal,Harrison M. Snodgrass,Christian A. Gomez,Jared C. Lewis
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2023-07-31
卷期号:123 (16): 10381-10431
被引量:7
标识
DOI:10.1021/acs.chemrev.3c00215
摘要
The ability to site-selectively modify equivalent functional groups in a molecule has the potential to streamline syntheses and increase product yields by lowering step counts. Enzymes catalyze site-selective transformations throughout primary and secondary metabolism, but leveraging this capability for non-native substrates and reactions requires a detailed understanding of the potential and limitations of enzyme catalysis and how these bounds can be extended by protein engineering. In this review, we discuss representative examples of site-selective enzyme catalysis involving functional group manipulation and C-H bond functionalization. We include illustrative examples of native catalysis, but our focus is on cases involving non-native substrates and reactions often using engineered enzymes. We then discuss the use of these enzymes for chemoenzymatic transformations and target-oriented synthesis and conclude with a survey of tools and techniques that could expand the scope of non-native site-selective enzyme catalysis.
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