Research Progress in Transition-Metal-Free C—Si Bond Formation

Organosilicons are widely used in many chemistry related fields.Given its important role, the chemical syntheses of organosilicon compounds have received considerable attention.Due to outstanding advantages in cost and environmental friendliness, transition-metal-free C-Si bond formation has been widely studied in the past decades and has been emerged as an important alternative to transition-metal-catalyzed C-Si cross-coupling.In this review, the recent developed methods of carbon-silicon bond formation under transition-metal-free conditions are summarized.The discussion is organized according to catalysts (acid catalysis, base catalysis, and radical initiation) and the types of C-Si bonds that formed.In addition, mechanistic discussions of representative reactions and a prospect for future development in this field are also briefly included.