发病机制
疾病
全基因组关联研究
酒精使用障碍
生物信息学
酒精性肝病
遗传关联
医学
风险因素
遗传学
生物
基因
酒
免疫学
单核苷酸多态性
病理
基因型
内科学
肝硬化
生物化学
作者
Trina M. Norden-Krichmar,Daniel M. Rotroff,Tae‐Hwi Schwantes‐An,Ramón Bataller,David Goldman,Laura E. Nagy,Suthat Liangpunsakul
标识
DOI:10.1097/hep.0000000000000617
摘要
Excessive alcohol use is a major risk factor for the development of an alcohol use disorder (AUD) and contributes to a wide variety of other medical illnesses, including alcohol-associated liver disease (ALD). Both AUD and ALD are complex and causally interrelated diseases, and multiple factors other than alcohol consumption are implicated in the disease pathogenesis. While the underlying pathophysiology of AUD and ALD is complex, there is substantial evidence for a genetic susceptibility of both diseases. Current genome-wide association studies indicate that the genes associated with clinical AUD only poorly overlap with the genes identified for heavy drinking and, in turn, neither overlap with the genes identified for ALD. Uncovering the main genetic factors will enable us to identify molecular drivers underlying the pathogenesis, discover potential targets for therapy, and implement patient care early in disease progression. In this review, we described multiple genomic approaches and their implications to investigate the susceptibility and pathogenesis of both AUD and ALD. We concluded our review with a discussion of the knowledge gaps and future research on genomic studies in these 2 diseases.
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