Catheter-guided endovenous cyanoacrylate closure is effective and safe in chronic venous insufficiency of the lower extremity: A Comparative Analysis

BackgroundCyanoacrylate adhesive closure (CAC) systems have become widely used in the treatment of varicose veins. In terms of efficacy and safety, these non-thermal non-tumescent methods have been reported to be noninferior to endovenous thermal ablation techniques. There are no known published studies that compare products using CAC. VenaSeal® (Medtronic, Santa Rosa, Ca, USA) and VenaBlockⓇ (Invamed, Ankara, Turkey) are among the most commonly used CAC-based products worldwide. This review article focuses on the efficacy and safety of these two different commonly used products.MethodsPublished full-text research articles regarding the VenaBlock^®System or the VenaSeal^ⓇSystem was searched. Data for each product were evaluated by comparing them with each other in terms of effectiveness and safety.ResultsA total of 1882 extremities from 11 studies with VenaBlock^®and 524 extremities from 8 studies with VenaSeal^Ⓡwere included and compared. Both devices were observed to be effective and cumulative recanalization-free survival rates were similar (p = 0.188) at the 6th, 12th, 24th, 36th and 60th month follow-ups. Both products were found to improve VCSS and QoL scores.ConclusionBoth devices were effective in terms of cumulative recanalization-free survival rates. Both significantly improved the venous clinical severity score and the quality of life scores. Cyanoacrylate adhesive closure is feasible in varicose vein treatment.