Genetic Insights Into Depression Induced by Tuberculosis via Mediating Roles of Interleukins: Evidence From Mendelian Randomization

Interleukin-1R2 may mediate depressive symptoms in tuberculosis patients, potentially through specific inhibition of interleukin-1-related inflammatory signalling. These findings elucidate genetic mechanisms underlying tuberculosis-depression comorbidity and suggest novel targets for preventive and therapeutic interventions.