自愈水凝胶
细胞外基质
材料科学
机械生物学
纳米技术
粘附
组织工程
细胞粘附
基质(水族馆)
弹性模量
弹性(物理)
生物医学工程
焦点粘着
生物物理学
复合材料
化学
细胞
解剖
高分子化学
生物
医学
生物化学
海洋学
地质学
作者
Qian Sun,Xiaokai Pan,Peng Wang,Qiang Wei
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-05-14
卷期号:24 (21): 6376-6385
被引量:36
标识
DOI:10.1021/acs.nanolett.4c01352
摘要
The fibrous extracellular matrix (ECM) is vital for tissue regeneration and impacts implanted device treatments. Previous research on fibrous biomaterials shows varying cellular reactions to surface orientation, often due to unclear interactions between surface topography and substrate elasticity. Our study addresses this gap by achieving the rapid creation of hydrogels with diverse fibrous topographies and varying substrate moduli through a surface printing strategy. Cells exhibit heightened traction force on nanopatterned soft hydrogels, particularly with randomly distributed patterns compared with regular soft hydrogels. Meanwhile, on stiff hydrogels featuring an aligned topography, optimal cellular mechanosensing is observed compared to random topography. Mechanistic investigations highlight that cellular force-sensing and adhesion are influenced by the interplay of pattern deformability and focal adhesion orientation, subsequently mediating stem cell differentiation. Our findings highlight the importance of combining substrate modulus and topography to guide cellular behavior in designing advanced tissue engineering biomaterials.
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