糖尿病
动物模型
糖尿病肾病
2型糖尿病
医学
肥胖
生物信息学
神经科学
内分泌学
生物
作者
Mark P. Keller,Kelly L. Hudkins,Anath Shalev,Sushant Bhatnagar,Melkam A. Kebede,Matthew J. Merrins,Dawn Belt Davis,Charles E. Alpers,Michelle E. Kimple,Alan D. Attie
出处
期刊:iScience
[Elsevier]
日期:2023-07-01
卷期号:26 (7): 107036-107036
被引量:2
标识
DOI:10.1016/j.isci.2023.107036
摘要
Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lepob mutation. We went on to discover that the BTBR-Lepob mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model.
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