软骨
骨关节炎
PLGA公司
透明质酸
骨愈合
关节软骨
药理学
生物医学工程
癌症研究
化学
医学
病理
体外
生物化学
解剖
外科
替代医学
作者
Liming Zheng,Sheng Zhao,Y Li,Rui‐Hua Xu,Wenjin Yan,Baosheng Guo,Jianbin Xu,Lifeng Jiang,Yifeng Zhang,Hui Wei,Qing Jiang
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-03-08
卷期号:10 (10)
标识
DOI:10.1126/sciadv.adk6084
摘要
The emerging therapeutic strategies for osteoarthritis (OA) are shifting toward comprehensive approaches that target periarticular tissues, involving both cartilage and subchondral bone. This shift drives the development of single-component therapeutics capable of acting on multiple tissues and cells. Magnesium, an element essential for maintaining skeletal health, shows promise in treating OA. However, the precise effects of magnesium on cartilage and subchondral bone are not yet clear. Here, we investigated the therapeutic effect of Mg 2+ on OA, unveiling its protective effects on both cartilage and bone at the cellular and animal levels. The beneficial effect on the cartilage-bone interaction is primarily mediated by the PI3K/AKT pathway. In addition, we developed poly(lactic- co -glycolic acid) (PLGA) microspheres loaded with nano-magnesium oxide modified with stearic acid (SA), MgO&SA@PLGA, for intra-articular injection. These microspheres demonstrated remarkable efficacy in alleviating OA in rat models, highlighting their translational potential in clinical applications.
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