细胞外基质
癌细胞
肿瘤微环境
表观遗传学
细胞代谢
间质细胞
生物
串扰
细胞外
新陈代谢
肿瘤异质性
癌症
细胞代谢
细胞生物学
细胞
癌症研究
生物化学
遗传学
物理
光学
基因
作者
Rodrigo Curvello,Nikolaus Berndt,Sandra Hauser,Daniela Loessner
标识
DOI:10.1016/j.tem.2023.12.005
摘要
Tumours are heterogeneous tissues containing diverse populations of cells and an abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to adapt their metabolism to survive and grow. Besides epigenetic factors, the metabolism of cancer cells is shaped by crosstalk with stromal cells and extracellular components. To date, most experimental models neglect the complexity of the tumour microenvironment and its relevance in regulating the dynamics of the metabolism in cancer. We discuss emerging strategies to model cellular and extracellular aspects of cancer metabolism. We highlight cancer models based on bioengineering, animal, and mathematical approaches to recreate cell-cell and cell-matrix interactions and patient-specific metabolism. Combining these approaches will improve our understanding of cancer metabolism and support the development of metabolism-targeting therapies.
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