材料科学
再生(生物学)
药品
活性氧
细菌
超声
伤口愈合
人口
微生物学
药理学
化学
医学
细胞生物学
免疫学
生物
环境卫生
色谱法
遗传学
作者
Chong Geng,Shuai He,Sheng Yu,Hannah M. Johnson,Hongxing Shi,Yanbai Chen,Yau Kei Chan,Wenxuan He,Miao Qin,Xiao Li,Yi Deng
标识
DOI:10.1002/adma.202310599
摘要
-bioHJs act as a "lever" that effectively achieves a balance between ROS generation and annihilation, delivering both antibacterial and anti-inflammatory properties to the engineered membrane. More importantly, in vivo assays corroborate that the nanocatalytic membranes transform the stalled chronic wound environment into a regenerative one by eradicating the bacterial population, dampening the NF-κB inflammatory pathway and promoting angiogenesis. As envisaged, this work demonstrates a novel tactic to arm membranes with programmed antibacterial and anti-inflammatory effects to remedy refractory infected wounds from drug-fast bacteria.
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