One-pot preparation of NiMn layered double hydroxide-MOF material for highly sensitive electrochemical sensing of glucose

To rationally design and construct electrocatalytic nanomaterials is crucial for improving the sensitivity and selectivity of non-enzyme-based electrochemical sensors. Here, NiMn layered double hydroxide (LDH)-based MOF (NiMn-LDH-MOF) material was used as electrochemical electrode for highly sensitive assay of glucose. The NiMn-LDH-MOF was firstly synthesized by one-pot method via directly blending MOF-74, metal nodes and ammonia. The obtained NiMn-LDH-MOF has an excellent electrocatalytic activity for electrochemical oxidation of glucose and the NiMn-LDH-MOF/GCE sensor exhibits a wide linear detection range from 4.9 μM to 2.2 mM, a low detection limit (0.87 μM, S/N = 3), and high sensitivity (0.849 mA mM−1 cm−2). Meanwhile, the sensor has good selectivity and reliability for glucose detection in actual serum samples, suggesting the potential applicability of the sensor for glucose detection. The more exposed active sites, the introduction of LDHs subunit and the synergistic effect between Ni and Mn in the NiMn-LDH-MOF are the major factors to enhance the assay performance.