材料科学
海绵
壳聚糖
止血
止血剂
伤口愈合
纳米技术
金黄色葡萄球菌
抗菌剂
生物医学工程
微生物学
化学
医学
细菌
外科
生物
生物化学
植物
遗传学
作者
Zikai Xu,Liangyu Zou,Feng Xie,Xi Zhang,Xiaolan Ou,Guanghui Gao
标识
DOI:10.1021/acsami.2c09309
摘要
Sponges with highly absorptive properties have been widely used in emergency hemostasis. Graphene oxide (GO) has been extensively investigated in biomedical applications and is a promising candidate for hemostatic sponges. However, GO has been demonstrated to have adverse effects on the human body. To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength. Importantly, hemostasis assays showed that the composite sponge exhibited high hemostatic efficiency, and the possible hemostatic mechanism is also discussed in this study. Moreover, the results of in vitro antibacterial tests reveal that the composite sponge also presents strong antimicrobial effects against Staphylococcus aureus and Escherichia coli. Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12. Such a graphene-based sponge with multiple advantageous features would hold broad prospects in the hemostatic field.
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