亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

免疫疗法 癌症研究 生发中心 抗体 免疫学 腺癌 肺癌 生物 癌症 免疫系统 B细胞 医学 病理 遗传学
作者
Kevin W. Ng,Jesse Boumelha,Katey S.S. Enfield,Jorge Almagro,Hongui Cha,Oriol Pich,Takahiro Karasaki,David A. Moore,Roberto Salgado,Monica Sivakumar,George R. Young,Míriam Molina‐Arcas,Sophie de Carné Trécesson,Panayiotis Anastasiou,Annika Fendler,Lewis Au,Scott T.C. Shepherd,Carlos Martínez-Ruiz,Clare Puttick,James R. Black,Thomas B.K. Watkins,Hye Min Kim,Seohee Shim,Nikhil Faulkner,Jan Attig,Selvaraju Veeriah,Neil Magno,Sophia Ward,Alexander M. Frankell,Maise Al Bakir,Emilia L. Lim,Mark S. Hill,Gareth A. Wilson,Daniel E. Cook,Nicolai J. Birkbak,Axel Behrens,Nadia Yousaf,Sanjay Popat,Allan Hackshaw,Andrew Rowan,Ariana Huebner,Brittany Campbell,Chris Bailey,Claudia Lee,Dhruva Biswas,Emma Colliver,Foteini Athanasopoulou,Hao‐Ran Zhai,Jayant K. Rane,Kristiana Grigoriadis,Michelle Dietzen,Michelle Leung,Mihaela Angelova,Olivia Lucas,Othman Al‐Sawaf,Rachel Rosenthal,Jérôme Nicod,Abigail Bunkum,Antonia Toncheva,Christopher Abbosh,Corentin Richard,Cristina Naceur‐Lombardelli,Francisco Gimeno-Valiente,Jie Min Lam,Kerstin Thol,Krupa Thakkar,Mariana Werner Sunderland,Martin Förster,Nnennaya Kanu,Paulina Prymas,Robert Bentham,Sadegh Saghafinia,Sergio A. Quezada,Sharon Vanloo,Simone Zaccaria,Siow Ming Lee,Sonya Hessey,Wing Kin Liu,Dionysis Papadatos-Pastos,James M. Wilson,Sarah Benafif,Tanya Ahmad,Elaine Borg,Mary Falzon,Reena Khiroya,Teresa Marafioti,Abigail Sharp,Camilla Pilotti,Harjot Kaur Dhanda,Kitty S. Chan,Nicole Gower,Rachel Leslie,Sean Smith,Andrew G. Nicholson,Eric Lim,Javier Herrero,Carla Castignani,Elizabeth Larose Cadieux,Jonas Demeulemeester,Peter Van Loo,Karl S. Peggs,Catarina Veiga,Gary Royle,Charles-Antoine Collins-Fekete,Alexander James Procter,Arjun Nair,Asia Ahmed,Magali Taylor,Neal Navani,Ricky M. Thakrar,David Lawrence,Davide Patrini,Emma Nye,Richard Stone,David Chuter,Mairead MacKenzie,Francesco Fraioli,Paul Ashford,Sam M. Janes,Miljana Tanić,Stephan Beck,Alexandra Rice,Anand Devaraj,Chiara Proli,Daniel Kaniu,Harshil Bhayani,Hema Chavan,Hilgardt Raubenheimer,Lyn Ambrose,Mpho Malima,Nadia Fernandes,Paulo De Sousa,Pratibha Shah,Sarah Booth,Silviu Buderi,Simon Jordan,Sofina Begum,Ekaterini Boleti,Grant D. Stewart,Alastair Magness,Clare E. Weeden,Dina Levi,Eva Grönroos,Jacki Goldman,Mickael Escudero,Philip Hobson,Roberto Vendramin,Stefan Boeing,Tamara Denner,Vittorio Barbè,Wei-Ting Lu,William Hill,Yutaka Naito,Zoe Ramsden,Anca Grapa,Hanyun Zhang,Khalid AbdulJabbar,Xiaoxi Pan,Kayleigh Gilbert,Angeliki Karamani,Benny Chain,David R. Pearce,Despoina Karagianni,Elena Hoxha,Felip Gálvez-Cancino,Georgia Stavrou,Gerasimos Mastrokalos,Helen Lowe,Ignacio Matos,James L. Reading,John A. Hartley,Kayalvizhi Selvaraju,Kezhong Chen,Leah Ensell,Mansi Shah,Marcos Vásquez,Maria Litovchenko,Olga Chervova,P. Pawlik,Robert E. Hynds,Saioa López,Samuel Gamble,Seng Kuong Anakin Ung,Supreet Kaur Bola,Thanos P. Mourikis,Victoria J. Spanswick,Yin Wu,Emilie Martinoni Hoogenboom,Fleur Monk,James W. Holding,Junaid Choudhary,Kunal Bhakhri,Marco Scarci,Martin Hayward,Νικόλαος Παναγιωτόπουλος,Pat Gorman,Robert Stephens,Steve Bandula,Yien Ning Sophia Wong,Tristan Clark,Heather Cheyne,Mohammed Khalil,Shirley Richardson,Tracey Cruickshank,Babu Naidu,Gurdeep Matharu,Jacqui A. Shaw,Joan Riley,Lindsay Primrose,John Le Quesne,Kevin G. Blyth,Alastair Kerr,Alexandra Clipson,Anshuman Chaturvedi,Caroline Dive,Dominic G. Rothwell,Elaine Kilgour,Jonathan Tugwood,Lynsey Priest,Pedro Oliveira,Philip Crosbie,Gillian Price,Judith Cave,Keith M. Kerr,Colin R. Lindsay,Fiona Blackhall,Matthew Krebs,Yvonne Summers,Alan Kirk,Mathew Thomas,Mo Asif,Nikos Kostoulas,Rocco Bilancia,Gary Middleton,Michael Shackcloth,Angela Leek,Jack Davies Hodgkinson,Nicola Totten,Craig Dick,Lily Robinson,Peter Russell,Madeleine Hewish,Sarah Danson,J.F. Lester,Fábio Gomes,Kate Brown,Mathew Carter,Akshay J. Patel,Aya Osman,Christer Lacson,Gerald Langman,Helen Shackleford,Madava Djearaman,Salma Kadiri,Aiman Alzetani,Jennifer Richards,Lydia Scarlett,Papawadee Ingram,Serena Chee,Silvia Austin,Amrita Bajaj,Apostolos Nakas,Azmina Sodha-Ramdeen,Dean A. Fennell,Keng Ang,Mohamad Tufail,Mohammed Fiyaz Chowdhry,Molly Scotland,Rebecca Boyles,Sridhar Rathinam,Claire Wilson,Domenic Marrone,Sean Dulloo,Ángeles Montero,Elaine Smith,Eustace Fontaine,Felice Granato,Helen Doran,Juliette Novasio,Kendadai Rammohan,Leena Dennis Joseph,Paul Bishop,Rajesh Shah,Stuart B. Moss,Vijay Joshi,Hugo J.W.L. Aerts,Tom L. Kaufmann,Roland F. Schwarz,Judit Kisistók,Mateo Sokač,Miklós Dióssy,Zoltán Szállási,Krijn K. Dijkstra,Yinyin Yuan,Fiona Byrne,Laura Amanda Boos,Benjamin Shum,Camille L. Gérard,Andreas M. Schmitt,Christina Messiou,David Cunningham,Ian Chau,Naureen Starling,Nicholas Turner,Liam Welsh,Robin L. Jones,Joanne Droney,Susana Banerjee,Kate Tatham,Shaman Jhanji,Kevin J. Harrington,Alicia Okines,Alison Reid,Kate Young,Andrew J.S. Furness,Lisa Pickering,Emma Nicholson,Sacheen Kumar,Katalin A. Wilkinson,Anthony Swerdlow,Robert J. Wilkinson,Crispin T. Hiley,Kevin Litchfield,Nicholas McGranahan,Mariam Jamal‐Hanjani,James Larkin,Se‐Hoon Lee,Samra Turajlic,Charles Swanton,Julian Downward,George Kassiotis
出处
期刊:Nature [Springer Nature]
卷期号:616 (7957): 563-573 被引量:69
标识
DOI:10.1038/s41586-023-05771-9
摘要

Abstract B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS) 1,2 . Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive 1,2 . Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma 3 . We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
pupcoco完成签到,获得积分10
刚刚
风度567完成签到,获得积分10
15秒前
共享精神应助Andy采纳,获得10
16秒前
18秒前
DrY发布了新的文献求助30
18秒前
CDQ完成签到,获得积分10
20秒前
luyee发布了新的文献求助10
22秒前
月亮煮粥发布了新的文献求助10
33秒前
36秒前
JamesPei应助科研通管家采纳,获得30
38秒前
夫诸完成签到 ,获得积分10
40秒前
楼北完成签到,获得积分10
43秒前
细心飞鸟完成签到,获得积分10
56秒前
Omni完成签到,获得积分10
1分钟前
mini的yr完成签到 ,获得积分10
1分钟前
xuzj完成签到,获得积分10
1分钟前
1分钟前
受伤翠容发布了新的文献求助10
1分钟前
1分钟前
受伤翠容完成签到,获得积分20
1分钟前
平常的凡白完成签到 ,获得积分10
1分钟前
dream177777完成签到 ,获得积分10
1分钟前
monicaj完成签到 ,获得积分10
1分钟前
cheese完成签到 ,获得积分10
2分钟前
SHUTUP发布了新的文献求助10
2分钟前
577kkmm完成签到 ,获得积分10
2分钟前
墨与白完成签到 ,获得积分10
2分钟前
唐汉发布了新的文献求助10
2分钟前
活泼的匕完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
2分钟前
兰兰发布了新的文献求助10
2分钟前
2分钟前
orixero应助兰兰采纳,获得10
3分钟前
3分钟前
吕懿发布了新的文献求助10
3分钟前
研友_VZG7GZ应助577kkmm采纳,获得10
3分钟前
情怀应助吕懿采纳,获得10
3分钟前
高兴的店员完成签到,获得积分10
3分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
行動データの計算論モデリング 強化学習モデルを例として 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2545278
求助须知:如何正确求助?哪些是违规求助? 2175612
关于积分的说明 5600084
捐赠科研通 1896314
什么是DOI,文献DOI怎么找? 946176
版权声明 565334
科研通“疑难数据库(出版商)”最低求助积分说明 503541