Glypican 3型
癌变
癌症研究
细胞生物学
糖基化
翻译后修饰
生物
疾病
功能(生物学)
癌症
肝细胞癌
化学
计算生物学
医学
生物化学
遗传学
病理
酶
作者
Emily Schepers,Kathryn Glaser,Harrison M Zwolshen,Stephen J. Hartman,Alexander Bondoc
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2023-04-07
卷期号:83 (12): 1933-1940
被引量:6
标识
DOI:10.1158/0008-5472.can-22-3895
摘要
Abstract Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in hepatocellular carcinoma (HCC). GPC3 undergoes extensive posttranslational modification (PTM) including cleavage and glycosylation. This review focuses on the structure and function of GPC3 in liver cancer, highlighting the PTM of the tertiary and quaternary structures of GPC3 as a potential oncogenic regulatory mechanism. We propose that the function of GPC3 in normal development can vary with extensive PTM and that dysregulation of these processes leads to disease. Defining the regulatory impact of these modifications can provide a deeper understanding of the role of GPC3 in oncogenesis, epithelial–mesenchymal transition, and drug development. Through review of current literature, this article provides a unique perspective on the role of GPC3 in liver cancer, focusing on potential regulatory mechanisms of PTM on GPC3 function at the molecular, cellular, and disease level.
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