材料科学
金黄色葡萄球菌
肺炎克雷伯菌
自愈水凝胶
微生物学
耐甲氧西林金黄色葡萄球菌
伤口愈合
伤口护理
细菌
化学
医学
高分子化学
生物
重症监护医学
外科
大肠杆菌
生物化学
基因
遗传学
作者
B. Zhang,Yuexiang Lu,Lei Huang,Ping Liu,Jun Ni,Tianqi Yang,Yihong Li,Yu Zhong,Xinping He,Xinhui Xia,Jiancang Zhou
标识
DOI:10.1002/adhm.202303688
摘要
Bacterial infections in wounds continue to be a major challenge in clinical settings worldwide and represent a significant threat to human health. This work proposes novel expandable and versatile methods for solidifying sodium alginate (SA) with metal ions (such as Fe3+ , Co2+ , Ni2+ , Cu2+ , and Zn2+ ) to create Metal-Alginate (M-Alg) hydrogel with adjustable morphology, composition, and microstructure. It conforms to the wound site, protects against second infection, reduces inflammation, and promotes the healing of infected wounds. Among these hydrogels, Cu-Alginate (Cu-Alg) shows excellent sterilization effect and good efficacy against both gram-positive and gram-negative bacteria, including multidrug-resistant (MDR) strains such as Methicillin-resistant Staphylococcus aureus (MRSA) and Carbapenem-resistant Klebsiella pneumoniae (CRKP) due to its dual antibacterial mechanisms: contact-killing and reactive oxygen species (ROS) burst. Importantly, it exhibits low cytotoxicity and biodegradability. This simple and cost-effective gel-based system has the potential to introduce an innovative approach to the management of wound infection and offers promising new perspectives for the advancement of wound care practice.
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