化学
外消旋化
立体选择性
Knoevenagel冷凝
氨基酸
有机化学
酯交换
钯
组合化学
催化作用
生物化学
作者
Annakaisa Heikinheimo,Martin Nieger,Ari M. P. Koskinen
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2022-12-04
摘要
Abstract Novel substituted chromenopyrrolidinones were synthesized from natural amino acid derivatives through an unprecedented route involving a Knoevenagel/transesterification sequence and an allylative palladium-catalyzed cyclization reaction. The products were nature-inspired heterocycles derived from natural amino acids. The targets were synthesized with varying degrees of stereoselectivity: racemization is a known issue with amino acids, and this provided a formidable challenge to our method development. In total, six derivatives were synthesized in moderate to good yields.
科研通智能强力驱动
Strongly Powered by AbleSci AI