化学
抗真菌
范围(计算机科学)
组合化学
广谱
生化工程
纳米技术
计算机科学
医学
工程类
皮肤病科
材料科学
程序设计语言
作者
Zahra Hosseinzadeh,Ali Ramazani,Kamaleddin Hosseinzadeh,Nima Razzaghi‐Asl,Farideh Gouranlou
出处
期刊:Current Organic Synthesis
[Bentham Science]
日期:2018-04-24
卷期号:15 (2): 166-178
被引量:21
标识
DOI:10.2174/1570179414666170908165445
摘要
Background: Pyrrolidinone is a five membered heterocyclic ring that is a versatile lead compound for designing powerful bioactive agents. Pyrrolidinone nucleus is one of the most important heterocyclic compound indicating notable pharmaceutical effects. Many procedures for the preparation of pyrrolidinone and also their various reactions offer great scope in the field of medicinal chemistry. This fascinating group of compounds has diverse pharmacological activities such as antibacterial, antifungal, anticancer and anticonvulsant. Objective: The review article proposes to classify comprehensive information on chemistry and pharmaceutical effects of pyrrolidinone in order to open new viewpoint for future studies. Conclusion: It is clear from the review of the topic that a wide spectrum of pyrrolidinone analogues have been synthesized and the majority of these derivatives have indicated different significant biological activities. Thus, these analogues can be used for future progression of novel drugs against many more poor agents.
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