叶酸受体
脂质体
炎症
免疫系统
癌症研究
银屑病
医学
靶向给药
关节炎
药理学
结肠炎
类风湿性关节炎
受体
免疫学
化学
药品
癌症
癌细胞
生物化学
内科学
作者
Scott Poh,Venkatesh Chelvam,Wilfredo Ayala-López,Karson S. Putt,Philip S. Low
标识
DOI:10.1016/j.nano.2018.01.009
摘要
Activated macrophages play a key role in the development and maintenance of inflammatory diseases such as atherosclerosis, lupus, psoriasis, rheumatoid arthritis, ulcerative colitis, and many others. These activated macrophages, but not resting or quiescent macrophages highly up-regulate folate receptor beta (FR-β). This differential expression of FR-β provides a mechanism to selectively deliver imaging and therapeutic agents utilizing folate as a targeting molecule. In an effort to determine whether inflammatory diseases can be targeted utilizing a folate-linked nanosize carrier, a PEG-coated liposome was prepared that incorporated a folate conjugated PEG that also could transport imaging or therapeutic cargo. We demonstrate that these folate-liposomes specifically bind to folate receptor positive cells and accumulate at sites of inflammation in mouse models of colitis and atherosclerosis. These two animal models show that folate-targeted liposomes could be successfully utilized to deliver fluorescent molecules and an anti-inflammatory drug (betamethasone) for diagnostic and therapeutic applications.
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