骆驼蓬
化学
生物碱
阿兹平
立体化学
碳骨架
吲哚试验
IC50型
去氢骆驼蓬碱
传统医学
植物
生物化学
生物
体外
药理学
医学
作者
Zhong‐Nan Wu,Neng‐Hua Chen,Qing Tang,Si Chen,Zhao‐Chun Zhan,Yubo Zhang,Guo‐Cai Wang,Yao-Lan Li,Wen‐Cai Ye
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-09-08
卷期号:22 (18): 7310-7314
被引量:33
标识
DOI:10.1021/acs.orglett.0c02650
摘要
Pegaharines A–G (1–6), six novel β-carboline alkaloids representing three types of skeleton, were isolated from the seeds of Peganum harmala. Compound 1 is a peculiar β-carboline alkaloid characterized by the unprecedented carbon skeleton of an azepine–indole system. Compounds 3–6 represent the first examples of heterodimers constructed from rare tetracyclic β-carboline and classic tricyclic β-carboline alkaloids. Compounds 1 and 2 were characterized by X-ray crystallography. Compound 4 exhibited strong antiviral activity against HSV-2, with an IC50 value of 2.12 ± 0.14 μM.
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