星形细胞瘤
主成分分析
病理
拉曼光谱
脑组织
脑瘤
脑癌
癌症
医学
胶质瘤
生物医学工程
计算机科学
癌症研究
内科学
人工智能
光学
物理
作者
Aneta Aniela Kowalska,Sylwia M. Berus,Marcin Kadej,Agnieszka Kamińska,Alicja M. Kmiecik,Katarzyna Ratajczak-Wielgomas,Tomasz Jurek,Łukasz Zadka
标识
DOI:10.1016/j.saa.2019.117769
摘要
Abstract One of the biggest challenge for modern medicine is to make a discrimination among healthy and cancerous tissues. Therefore, nowadays big effort of scientist are devoted to find a new way for as fast as possible diagnosis with as much as possible accuracy in distinguishing healthy from cancerous tissues. That issues are probably the most important in the case of brain tumours, when the diagnosis time plays a great role. Herein we present the surface-enhanced Raman spectroscopy (SERS) together with the principal component analysis (PCA) used to identify the spectra of different brain specimens, healthy and tumour tissues homogenates. The presented analyses include three sets of brain tissues as control samples taken from healthy objects (one set consists of samples from four brain lobes and both hemispheres; eight samples) and the brain tumours from five patients (two Anaplastic Astrocytoma and three Glioblastoma samples). Results prove that tumour brain samples can be discriminated well from the healthy tissues by using only three main principal components, with 96% of accuracy. The largest influence onto the calculated separation is attributed to the spectral regions corresponding in SERS spectra to vibrations of the L-Tryptophan (1450, 1278 cm−1), protein (1300 cm−1), phenylalanine and Amide-I (1005, 1654 cm−1). Therefore, the presented method may open the way for the probable application as a very fast diagnosis tool alternative for conventionally used histopathology or even more as an intraoperative diagnostic tool during brain tumour surgery.
科研通智能强力驱动
Strongly Powered by AbleSci AI