孟德尔随机化
医学
冠状动脉疾病
冲程（发动机）
优势比
心脏病学
全基因组关联研究
内科学
单核苷酸多态性
遗传学
基因型
遗传变异
生物
机械工程
基因
工程类
作者
Michael G. Levin,Derek Klarin,Themistocles L. Assimes,Matthew S. Freiberg,Erik Ingelsson,Julie A. Lynch,Pradeep Natarajan,Christopher J. O’Donnell,Daniel J. Rader,Philip S. Tsao,Kyong‐Mi Chang,Benjamin F. Voight,Scott M. Damrauer,VA Million Veteran Program
出处
期刊：JAMA network open
[American Medical Association]
日期：2021-01-19
卷期号：4 (1): e2034461-e2034461
被引量：75
标识
DOI：10.1001/jamanetworkopen.2020.34461
摘要
In this mendelian randomization analysis of data from large studies of atherosclerotic cardiovascular diseases, genetic liability to smoking was a strong risk factor for CAD, PAD, and stroke, although the estimated association was strongest between smoking and PAD. The association between smoking and atherosclerotic cardiovascular disease was independent of traditional cardiovascular risk factors.
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