声穿孔
阿霉素
纳米载体
材料科学
纳米颗粒
氧化铁纳米粒子
纳米囊
药物输送
纳米技术
癌细胞
纳米团簇
磁共振成像
生物物理学
化学
生物医学工程
超声波
癌症
化疗
微气泡
医学
外科
放射科
内科学
生物
作者
Jia Liang,Xin Li,Hui Liu,Jindong Xia,Xiangyang Shi,Mingwu Shen
出处
期刊:Nano Today
[Elsevier]
日期:2021-02-01
卷期号:36: 101022-101022
被引量:84
标识
DOI:10.1016/j.nantod.2020.101022
摘要
Design of novel theranostic nanoplatforms integrating precision dynamic imaging modalities, tumor targeting ligands and therapeutic components with enhanced tumor accumulation still remains to be challenging. Here we report a facile strategy to prepare cell membrane (CM)-coated nanoclusters assembled from ultrasmall iron oxide nanoparticles (USIO NPs) with pH-responsiveness as a nanocarrier to load anti-cancer drug doxorubicin (DOX). Citric-stabilized USIO NPs with a size of 3.2 nm were synthesized, modified to have surface amine groups, and crosslinked to obtain pH-responsive nanoclusters (NCs). Then, the formed USIO NCs were loaded with DOX, and coated with cancer CMs to render them with resistance to macrophage cellular uptake and homologous cancer cell targeting specificity. Within the acidic tumor microenvironment, the pH-responsive USIO NCs/[email protected] with dominant T2 magnetic resonance (MR) imaging performance can be dissociated to form single USIO NPs with T1 MR imaging ability, and simultaneously rapidly release DOX, thereby enabling dynamic T2/T1-weighted MR imaging and chemotherapy of tumors. Further, through the ultrasound-induced sonoporation effect, the dynamic MR imaging and tumor chemotherapy can be further enhanced. The designed USIO NCs/[email protected] may be developed as a versatile theranostic platform for ultrasound-enhanced targeted precision theranostics of different cancer types.
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