生物
基因组
基因组组织
功能(生物学)
机械转化
计算生物学
染色质
核孔
细胞质
遗传学
细胞生物学
DNA
基因
作者
Xianrong Wong,Tsui-Han Loo,Colin L. Stewart
标识
DOI:10.1016/j.gde.2020.12.007
摘要
The regulation of genomic function is in part mediated through the physical organization and architecture of the nucleus. Disruption to nuclear organization and architecture is increasingly being recognized by its contribution to many diseases. The LINC complexes - protein structures traversing the nuclear envelope, that physically connect the nuclear interior, and hence the genome, to cytoplasmic cytoskeletal networks are an important component in the physical organization of the genome and its function. This connection, potentially allows for the constant detection of environmental mechanical stimuli, resulting in altered regulation of nuclear architecture and genome function, either directly or via the process of mechanotransduction. Here, we review the influences LINC complexes exert on genome functions and their impact on cellular/organismal health.
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