钯
催化作用
区域选择性
化学
化学选择性
腈
芳基
烷基化
有机化学
组合化学
烷基
作者
Ying‐Chu Lin,Leiyang Lv,Zihang Qiu,Zhangpei Chen,Ze Tan,Yu‐Feng Liang,Chao‐Jun Li
标识
DOI:10.1002/anie.202005132
摘要
Abstract We have developed an unprecedented Pd‐catalyzed formal hydroalkylation of alkynes with hydrazones, which are generated in situ from naturally abundant aldehydes, as both alkylation reagents and hydrogen donors. The hydroalkylation proceeds with high regio‐ and stereoselectivity to form ( Z )‐alkenes, which are more difficult to generate compared to ( E )‐alkenes. The reaction is compatible with a wide range of functional groups, including hydroxy, ester, ketone, nitrile, boronic ester, amine, and halide groups. Furthermore, late‐stage modifications of natural products and pharmaceutical derivatives exemplify its unique chemoselectivity, regioselectivity, and synthetic applicability. Mechanistic studies indicate the possible involvement of Pd‐hydride intermediates.
科研通智能强力驱动
Strongly Powered by AbleSci AI