热重分析
壳聚糖
差示扫描量热法
结晶度
热稳定性
材料科学
化学工程
傅里叶变换红外光谱
溶解度
维卡软化点
扫描电子显微镜
肿胀 的
高分子化学
核化学
化学
有机化学
复合材料
软化点
工程类
物理
热力学
作者
Yhors Ciro,John Rojas,Cristhian J. Yarce,Constaín H. Salamanca
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2020-01-01
卷期号:: 671-688
标识
DOI:10.1016/b978-0-12-817966-6.00021-2
摘要
Glutathione–chitosan derivatives were synthesized via carbodiimide and N-hydroxysuccinimide reaction for 24, 72, and 120 h. Fourier-transform infrared spectroscopy, 1H nuclear magnetic resonance spectroscopy,X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, bacterial endotoxins test, and scanning electron microscope analyses were used for product characterization. The films were prepared by the casting-evaporation method and the release properties were evaluated at a pH of 4.5 and 6.8. Different release models were used to explain the release mechanism from the films. These thiolated products showed an increased melting point, porosity, and specific surface area implying a major thermal stability as compared to chitosan, especially those having a thiolation degree of 1% and 6%. Thiolation was associated with a loss of crystallinity of chitosan. Further, the release of cyclophosphamide from the films depended on the thiolation degree rather than the medium pH. This is explained by the high aqueous solubility of the drug and high film porosity triggered by thiolation. Moreover, the swelling ability and flexibility of the membranes decreased with thiolation, but did not affect drug release. These glutathione–chitosan-based films have a potential for use as an alternative vehicle for controlled release of drugs.
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