人巨细胞病毒
水痘带状疱疹病毒
槲皮素
体外
化学
病毒学
乙酸乙酯
病毒
分数(化学)
细胞毒性T细胞
乙醇
生物
生物化学
色谱法
抗氧化剂
作者
Chae Hyun Kim,Jung-Eun Kim,Young-Bo Song
出处
期刊:Molecules
[MDPI AG]
日期:2020-05-20
卷期号:25 (10): 2379-2379
被引量:47
标识
DOI:10.3390/molecules25102379
摘要
We previously reported that the ethyl acetate (EtOAc) fraction of a 70% ethanol extract of Elaeocarpus sylvestris (ESE) inhibits varicella-zoster virus (VZV) and human cytomegalovirus (HCMV) replication in vitro. PGG (1,2,3,4,6-penta-O-galloyl-ß-D-glucose) is a major chemical constituent of the EtOAc fraction of ESE that inhibits VZV but not HCMV replication. In this study, we comprehensively screened the chemical compounds identified in the EtOAc fraction of ESE for potential antiviral properties. Among the examined compounds, quercetin and isoquercitrin displayed potent antiviral activities against both VZV and HCMV with no significant cytotoxic effects. Both compounds strongly suppressed the expression of VZV and HCMV immediate–early (IE) genes. Our collective results indicated that, in addition to PGG, quercetin and isoquercitrin are bioactive compounds in the EtOAc fraction of ESE that effectively inhibit human herpesvirus replication.
科研通智能强力驱动
Strongly Powered by AbleSci AI