微量营养素
干细胞
生物
癌变
平衡
生理学
细胞生物学
癌症研究
肠上皮
癌症
医学
病理
遗传学
作者
Gizem Calibasi-Kocal,Omid Mashinchian,Yasemin Basbinar,Ender Ellidokuz,Chia-Wei Cheng,Ömer H. Yilmaz
标识
DOI:10.1016/j.tem.2020.11.003
摘要
Food and nutrition have a profound impact on organismal health and diseases, and tissue-specific adult stem cells play a crucial role in coordinating tissue maintenance by responding to dietary cues. Emerging evidence indicates that adult intestinal stem cells (ISCs) actively adjust their fate decisions in response to diets and nutritional states to drive intestinal adaptation. Here, we review the signaling mechanisms mediating the dietary responses imposed by caloric intake and nutritional composition (i.e., macronutrients and micronutrients), fasting-feeding patterns, diet-induced growth factors, and microbiota on ISCs and their relevance to the beginnings of intestinal tumors.
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