化学
吡啶
抗菌活性
溴化物
氢氧化钠
细菌
核化学
体外
硝基
金黄色葡萄球菌
氢氧化物
药物化学
有机化学
生物化学
生物
烷基
遗传学
作者
Ablo Evrard,Siomenan Coulibali,Daouda Touré,Souleymane Coulibaly,Ahmont Landry Claude Kablan,Fernique Konan Kouadio,Drissa Sissouma,Nathalie Guessend Kouadio,Ané Adjou
标识
DOI:10.1080/00397911.2022.2032175
摘要
To explore the antibacterial activity, a set of new 2-thiobenzyl-3-nitro-imidazo[1,2-a]pyridine derivatives were synthesized (9a–h) and characterized by NMR 1H, 13C and high-resolution mass (HRMS). These compounds were obtained by interaction between the 3-nitro-imidazo[1,2-a]pyridine isothiouronium salt (7) with benzyl chloride or bromide (8) in the presence of sodium hydroxide (NaOH). Eight (9a–h) of them were evaluated in vitro on the positive gram bacterium (S. aureus ATCC 29213) and two others negative gram bacteria (P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21) by methods diffusion in solid medium and liquid macrodilution. Five among the eight compounds (9a, 9d, 9h, 9f and 9g) showed significant antibacterial activity on P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21with MIC between 7.81 and 250 µg/mL. All compounds were inactive on S. aureus. The compounds 9a and 9g were more potent on the two strains of P. aeruginosa ATCC 27853.
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