氟尿嘧啶
抗药性
Wnt信号通路
药品
药理学
癌症研究
癌症
代谢物
医学
信号转导
生物
内科学
生物化学
遗传学
作者
Fahima Danesh Pouya,Yousef Rasmi,Mohadeseh Nemati
标识
DOI:10.1080/07357907.2022.2055050
摘要
Anti-metabolite drugs prevent the synthesis of essential cell growth compounds. 5-fluorouracil is used as an anti-metabolic drug in various cancers in the first stage of treatment. Unfortunately, in some cancers, 5-fluorouracil has low effectiveness because of its drug resistance. Studies have shown that drug resistance to 5-fluorouracil is due to the activation of specific signaling pathways and increased expressions of enzymes involved in drug metabolites. However, when 5-fluorouracil is used in combination with other drugs, the sensitivity of cancer cells to 5-fluorouracil increases, and the effect of drug resistance is reversed. This study discusses how the function of 5-fluorouracil in JAK/STAT, Wnt, Notch, NF-κB, and hedgehogs in some cancers.
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