医学
免疫学
白色念珠菌
银屑病
慢性皮肤黏膜念珠菌病
CD8型
白细胞介素
先天性淋巴细胞
细胞因子
先天免疫系统
免疫系统
生物
疾病
微生物学
病理
作者
Mika Yamanaka‐Takaichi,Soha Ghanian,David A. Katzka,Rochelle R. Torgerson,Afsáneh Alavi
标识
DOI:10.1007/s40257-022-00686-z
摘要
Anti-interleukin (IL)-17 agents have shown excellent therapeutic efficacy in patients with psoriasis and are expected to be expanded to other chronic inflammatory diseases. However, patients receiving anti-IL-17 agents are at an increased risk of developing Candida infection, with some agents reported to increase the incidence in a dose-dependent manner. Interleukin-17 is secreted by the Th17 subset of CD4+ lymphocytes, CD8+ T cells, and innate cells, including natural killer T cells, lymphoid tissue inducer cells, innate lymphoid cells, and γδ-T cells, and plays an important role in antifungal defense. Genetic defects in the IL-17-signaling pathway in both humans and animal models render susceptibility to candidiasis caused by Candida albicans. The purpose of this narrative review is to evaluate the literature on the role of IL-17 in protection against candidiasis, the prevalence of candidiasis in anti-IL-17 agent use, and to offer clinical recommendations on the diagnosis and management of anti-IL-17 medication-associated candidiasis.
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