Mn-mediated reductive C(sp3)–Si coupling of activated secondary alkyl bromides with chlorosilanes

The construction of secondary alkylsilanes is a challenging subject in the synthetic community. The cross-coupling provides a practical solution to address this problem, but it typically relies on organometallic species. Herein, we report an Mn-mediated reductive C(sp3)–Si coupling to synthesize these compounds from alkyl and silyl electrophiles. This approach avoids the requirement for activation of Si–Cl by transition metals and thus allows for the coupling of various common chlorosilanes. The reaction proceeds under mild conditions and shows good functional group compatibility. The method offers access to α-silylated organophosphorus and sulfones with a scope that is complementary to those obtained from the established methods.