内部核糖体进入位点
翻译(生物学)
基因亚型
计算生物学
生物
核糖核酸
环状RNA
真核翻译
核糖体
蛋白质生物合成
信使核糖核酸
细胞生物学
遗传学
基因
作者
Shuo‐Yang Wen,Javeria Qadir,Burton B. Yang
标识
DOI:10.1016/j.molmed.2022.03.003
摘要
In recent years, significant attention has focused on circular RNA (circRNA) translation to determine its clinical significance. Cap-independent translation of circRNAs driven by an internal ribosome entry site (IRES) or an N6-methyladenosine (m6A)-containing short sequence is different from the canonical cap-dependent translation of linear mRNAs. New proteins or isoforms possessing novel physiological roles can be generated from translatable circRNAs. The present review describes the elements involved in circRNA translation, and the functions of the translated novel protein isoforms in human diseases. Bifunctional characteristics of translatable circRNAs exerted by the circRNAs and the translated proteins are also discussed. Furthermore, various molecular strategies that could be used as appropriate therapeutic options are proposed.
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