Analysis of the mechanism by which TSLP production is inhibited by PHD inhibitors

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays an important role in the regulation of skin immunity and is upregulated in the lesions of atopic dermatitis patients. Therefore, inhibitors of TSLP production are effective as therapeutic agents for atopic dermatitis. In our laboratory, we found that hypoxia condition and DMOG, a PHD inhibitor, suppressed the expression of TSLP in keratinocytes. In this study, we analyzed the mechanism by which PHD inhibitors suppress TSLP expression.