总状芦笋
植物化学
化学
药理学
餐后
体内
保健品
槲皮素
过剩4
生物利用度
葡萄糖摄取
传统医学
生物化学
糖尿病
生物
胰岛素
药用植物
医学
内分泌学
生物技术
抗氧化剂
作者
Alka Raj Pandey,Shadab Ahmad,Satyendra Singh,Anjali Mishra,Amol Chhatrapati Bisen,Gaurav Sharma,Ishbal Ahmad,Sanjeev K. Shukla,Rabi Sankar Bhatta,Sanjeev Kanojiya,Akhilesh K. Tamrakar,Koneni V. Sashidhara
出处
期刊:Phytochemistry
[Elsevier]
日期:2022-09-01
卷期号:201: 113286-113286
被引量:6
标识
DOI:10.1016/j.phytochem.2022.113286
摘要
Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-β-glucopyranoside, liquiritigenin 4׳-O-β-apiofuranosyl-(1 → 2)-β-glucopyranoside and β-glucogallin for the first time from the roots of Asparagus racemosus. Isolated saponins were screened for their antidiabetic potential in L6-GLUT4myc myotubes in vitro followed by an in vivo evaluation in streptozocin-induced diabetic rats and db/db mice. Furoasparoside E produced a notable decrease in the postprandial blood glucose profile, in leptin receptor-deficient db/db mice, type 2 diabetes model. The effect of furoasparoside E on GLUT4 translocation was found to be mediated by the AMPK-dependent signaling pathway in L6-GLUT4myc myotubes. Moreover, it emerged as a stable plant metabolite with higher bioavailability and efficacy in in vivo pharmacokinetic studies. Therefore, these studies indicated that furoasparoside E may serve as a propitious lead for the management of type 2 diabetes and its secondary complications from natural source.
科研通智能强力驱动
Strongly Powered by AbleSci AI