荧光原位杂交
慢性粒细胞白血病
细胞遗传学
白血病
骨髓
生物
染色体易位
髓系白血病
融合基因
病理
髓样
免疫分型
癌症研究
医学
免疫学
染色体
流式细胞术
基因
遗传学
作者
C. Cameron Yin,L. Jeffrey Medeiros,Armand B. Glassman,Pei Lin
出处
期刊:American Journal of Clinical Pathology
[Oxford University Press]
日期:2004-06-01
卷期号:121 (6): 836-842
被引量:21
标识
DOI:10.1309/h8jh-6l09-4b9u-3hgt
摘要
The blast phase of chronic myelogenous leukemia (CML) frequently is associated with cytogenetic evidence of clonal evolution, defined as chromosomal aberrations in addition to the t(9;22)(q34;q11.2). We identified the t(8;21)(q22;q22) and other cytogenetic abnormalities by conventional cytogenetics and fluorescence in situ hybridization in 2 patients with t(9;22)-positive CML at the time of blast phase. The t(8;21), which typically is associated with a distinct subtype of de novo acute myeloid leukemia (AML) carrying the aml1/eto fusion gene, was accompanied by increased bone marrow myeloblasts (33%) in case 1 and extramedullary myeloid sarcoma in case 2, suggesting its possible role in disease progression. In case 1, the leukemic cells in aspirate smears had salmon-colored cytoplasmic granules, and immunophenotypic studies showed that the blasts expressed CD19. These findings suggest that the pathologic features of blast phase CML with the t(8;21) resemble those of de novo AML with the t(8;21).
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