前额叶皮质
神经科学
海马体
雷特综合征
海马结构
MECP2
心理学
自闭症谱系障碍
自闭症
认知
生物
发展心理学
生物化学
基因
表型
作者
Mary L. Phillips,Holly Robinson,Lucas Pozzo-Miller
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2019-05-21
卷期号:8
被引量:128
摘要
Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC projection is hyperactive in the Mecp2 knockout mouse model of the autism spectrum disorder Rett syndrome, which has deficits in social memory. Long-term excitation of mPFC-projecting vHIP neurons in wild-type mice impaired social memory, whereas their long-term inhibition in Rett mice rescued social memory deficits. The extent of social memory improvement was negatively correlated with vHIP-evoked responses in mPFC slices, on a mouse-per-mouse basis. Acute manipulations of the vHIP-mPFC projection affected social memory in a region and behavior selective manner, suggesting that proper vHIP-mPFC signaling is necessary to recall social memories. In addition, we identified an altered pattern of vHIP innervation of mPFC neurons, and increased synaptic strength of vHIP inputs onto layer five pyramidal neurons as contributing factors of aberrant vHIP-mPFC signaling in Rett mice.
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