免疫学
过继性细胞移植
卵清蛋白
炎症
整合素αM
医学
体内
敏化
过敏性炎症
流式细胞术
免疫系统
T细胞
生物
生物技术
作者
Negar Nowroozilarki,Hasan Halit Öz,Carolin Schroth,Andreas Hector,Bernd Nürnberg,Dominik Hartl,Saeed Kolahian
标识
DOI:10.1016/j.imlet.2018.10.007
摘要
Asthma is a chronic inflammatory disease driven by overactivation of T helper cell type 2 (Th2) responses. In the present study, we investigated the functional relevance of CD11b+Ly6G+ neutrophilic cells in allergic airway inflammation in vivo. Allergic airway inflammation in mice was induced by house dust mite (HDM) or ovalbumin (OVA) sensitization and challenge. CD11b+Ly6G+ neutrophilic cells and T cell phenotypes were quantified by flow cytometry. To assess the functional in vivo relevance, CD11b+Ly6G+ neutrophilic cells were adoptively transferred intravenously or intratracheally and consequences on airway inflammation were studied. Adoptively transferred CD11b+Ly6G+ neutrophilic cells attenuated Th2 and Th17 responses and airway inflammation in vivo. Collectively, our results demonstrate that CD11b+Ly6G+ neutrophilic cells suppress airway inflammation in allergic mice in vivo. Adoptive cellular transfer of suppressive neutrophilic cells may represent an attractive therapeutic strategy for allergic airway inflammation.
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