咪唑
配体(生物化学)
化学
药物化学
齿合度
摩尔电导率
过渡金属
八面体
金属
水溶液中的金属离子
八面体分子几何学
核化学
立体化学
无机化学
离子
有机化学
催化作用
受体
生物化学
作者
Israa N. Witwit,Husham M. Hasan Mubark,Hutham Mahmood Yousif Al-Labban,Ahmed Abdul Jabbar Jaloob Aljanaby
出处
期刊:International Journal of Research in Pharmaceutical Sciences
[GP Innovations Pvt. Ltd.]
日期:2019-07-12
卷期号:10 (3)
被引量:5
标识
DOI:10.26452/ijrps.v10i3.1382
摘要
New imidazole azo ligand (DPIDA) was prepared by coupling reaction between 4,5-di phenyl imidazole and N1,N1-dimethylbenzene1,4-diamine di hydrochloride and studied the complexation of this ligand with Mn(II) , Co(II) , Ni(II) , Cu(II) , Zn(II) , Cd(II) , and Hg(II) ions , The free ligand and it’s complexes characterized by Mass, 1HNMR, IR, UV-Vis. , and molar conductivity that indicated the octahedral geometry of them with a bidentate ligand which coordinated from (N3) atom of imidazole ring and one nitrogen atom of azo group.Biological activity of ligand (DPIDA) and it's complexes tested against two multi-drug resistant aerobic pathogenic bacteria isolated from patients with a burn. Three concentrations were selected (50, 100, 150) mg/ml for each crud synthesized derivative compounds. The derivative compound (4,5-diphenyl imidazole) with concentration 150mg/ml had an excellent antibacterial effect against Staphylococcus aureus and Pseudomonas aeruginosa with inhibition zone 21.83 ± 0.1764 mm and 24.30 ± 0.4163 mm respectively.
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