Progress on the Relationship between ERK,JNK Signal Transduction Pathway and Diseases

At present,most studies suggest that activation of ERK signaling pathway can promote cell proliferation and JNK signaling pathway are closely related with apoptosis.They are also involved in the pathophysiology change process of many diseases.JNK signal transduction pathway is closely related with neurodegenerative disease or other neurological diseases.ERK signal transduction pathway may be the main mechanism of tumorgenesis and invasiveness,which is also involved in the generation of pains.ERK intracellular localization may be closely related with neuro denaturation.