The effect of helicobacter pylori in intestinal metaplasia and atrophic gastritis

Objective To explore the mechanism of helicobacter pylori(Hp) infection in intestinal metaplasia of gastric mucosa and atrophic gastritis.Methods Totally 226 cases with Hp-positive were divided into treatment group(136 cases,Hp eradication therapy) and control group(130 cases,placebo therapy) randomly.To compare the degree of intestinal metaplasia,progression of atrophic gastritis,activity of telomerase,expression of Survivin mRNA between two groups.And compare pre and post treatment intragroups.Results It showed that higher expression of Survivin in intestinal metaplasia and atrophic gastritis.The Hp eradication therapy could reverse the intestinal metaplasia, release the progression of atrophic gastritis,reduce the expression of Survivin and inhibit the telomerase activity. It showed statistical significance in treatment group than control group(P0.01).Conclusion The Hp eradication therapy could help inhibit telomerase activity and expression of Survivin mRNA,to prevent the intestinal metaplasia.