Anti-stress Effect of Chinese Yam Polysaccharides in Mice

The aim of the study was to investigate the mechanism of the anti-stress effect of Chinese yam polysaccharides(YP) in mice.A total of 120 male Kunming mice of SPF grade were randomly divided into 4 groups:normal control(0 mg /(kg·d)),low dosages group(100 mg /(kg·d)),middle dosages group(200 mg /(kg·d)) and high dosages group of YP(400 mg /(kg·d)).At the end of the 30 day's administration,exhaustive swimming time,liver glycogen,serum urea nitrogen and blood lactic acid content were determined to evaluated the anti-stress effect.Compared with the control,the exhaustive swimming time of middle dosages and high dosages groups significantly increased by 99.03% and 199.64%,respectively.The liver glycogen content of middle dosages and high dosages groups significantly increased by 73.44% and 154.39%,respectively.The serum urea nitrogen content of middle dosages and high dosages groups significantly decreased by 28.44% and 43.75%,respectively.The blood lactic acid content of middle dosages and high dosages groups significantly decreased by 15.22% and 24.29%,respectively.The low dosages group showed no significant difference compared with the control.The results of the study indicated that YP was able to significantly alleviate the stress with a dose-dependent manner in mice.