Helicobacter pylori(Hp) infection can cause gastritis and peptic ulcer.The genotyping can show the essence of life.Different genotyping is correlated with different diseases and different genotyping correlated with different resistances.This article observed the Hp genotyping.There were four aspects to discuss:The correlation on different genotyping with the disease;different genotyping resistant;the different genotyping mucosal damage intensity;intervention link of traditional Chinese medicine.A brief summary of the nearly seven years of Hp genotyping research provides a new method to discover new drugs for the treatment of Hp with traditional Chinese medicine.