CXC chemokine ligand 10 and cardiovascular diseases

CXC chemokine ligand 10( CXCL10),also known as interferon-inducible protein-10( IP-10),is a small chemokine belonging to the non-ELR-CXC chemokine family,which plays a pivotal role in leukocyte trafficking and cellular and tissue functions,such as endothelial and vascular smooth muscle cells. CXCL10 is able to regulate a cascade of inflammatory responses by binding to specific CXCR3 receptor,regarded as vital manifestations in cardiovascular diseases( CVD). The purpose of this review is to describe the functions of CXCL10 in different CVDs and discuss the possibility of utilizing CXCL10 as a potential biomarker in CVD study pattern.