The expression of angiopoietin-2 and its significance in placenta of pregnant women with FGR

Objective: To detect the expression of angiopoietin-2(Ang-2)in placentas,and to evaluate the role of Ang-2 in FGR.Methods: Immunohistochemistry(SP) was used to investigate the distribution and location of angiopoietin-2 and the semi-quantitative method of reverse transcription polymerase chain reaction(RT-PCR) was employed to investigate the mRNA expression levels of angiopoietin-2 in placenta tissues of normal pregnant women and women with FGR.Results:1.S-P:(1)Ang-2 was located in trophoblast,endothelial cells and paravascular cells of placentas.(2)The mean density of angiopoietin-2 in group of FGR was significantly lower than that in normal group(P0.05).2.RT-PCR: Compared with the normal group,the mRNA expression levels of angiopoietin-2 was reduced(P0.05).Conclusion: The expression of Ang-2 was greatly reduced in late pregnancy,It maybe play an important role in the pathogenic causes of preeclampsia.