选择性
合理设计
克
纳米颗粒
配体(生物化学)
共价键
化学
胶体金
表面电荷
纳米技术
生物物理学
组合化学
材料科学
细菌
生物化学
有机化学
受体
生物
物理化学
催化作用
遗传学
作者
Pramod P. Pillai,Bartłomiej Kowalczyk,Kristiana Kandere‐Grzybowska,Magdalena Borkowska,Bartosz A. Grzybowski
标识
DOI:10.1002/anie.201602965
摘要
Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram-selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [-] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non-covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/-] nanoparticles are effective in low doses, are non-toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro)molecular level.
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