医学
迷走神经张力
呼吸系统
潮气量
通风(建筑)
麻醉
心脏病学
内科学
心率
呼吸生理学
到期
血压
自主神经系统
机械工程
工程类
作者
Junichiro Hayano,Fumihiko Yasuma,Akiyoshi Okada,Sonoyo Mukai,Takao Fujinami
出处
期刊:Circulation
[Ovid Technologies (Wolters Kluwer)]
日期:1996-08-15
卷期号:94 (4): 842-847
被引量:273
标识
DOI:10.1161/01.cir.94.4.842
摘要
Background The primary mechanisms of respiratory sinus arrhythmia (RSA) are understood to be the modulation of cardiac vagal efferent activity by the central respiratory drive and the lung inflation reflex, and the degree of RSA increases with cardiac vagal activity. However, it is unclear whether RSA serves an active physiological role or merely reflects a passive cardiovascular response to respiratory input. We hypothesized that RSA benefits pulmonary gas exchange by matching perfusion to ventilation within each respiratory cycle. Methods and Results In seven anesthetized dogs, a model simulating RSA was made. After elimination of endogenous autonomic activities, respiration-linked heartbeat fluctuations were generated by electrical stimulation of the right cervical vagus during negative pressure ventilation produced by phrenic nerve stimulation (diaphragm pacing). The vagal stimulation was performed in three conditions: phasic stimulation during expiration (artificial RSA) and during inspiration (inverse RSA) and constant stimulation (control) causing the same number of heartbeats per minute as the phasic stimulations. Although tidal volume, cardiac output, and arterial blood pressure were unchanged, artificial RSA decreased the ratio of physiological dead space to tidal volume (V d /V t ) and the fraction of intrapulmonary shunt (Q sp /Q t ) by 10% and 51%, respectively, and increased O 2 consumption by 4% compared with control. Conversely, reverse RSA increased V d /V t and Q sp /Q t by 14% and 64%, respectively, and decreased O 2 consumption by 14%. Conclusions These results support our hypothesis that RSA benefits the pulmonary gas exchange and may improve the energy efficiency of pulmonary circulation by “saving heartbeats.”
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