环糊精
PLGA公司
Zeta电位
药品
纳米颗粒
药物输送
材料科学
化学
乳状液
化学工程
纳米技术
核化学
色谱法
有机化学
药理学
工程类
医学
作者
Paola Mura,Francesca Maestrelli,Matteo Cecchi,Marco Bragagni,António J. Almeida
标识
DOI:10.3109/02652040903515508
摘要
A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded NPs, prepared by double-emulsion, were examined for dimensions, zeta-potential and entrapment efficiency. Solid-state studies demonstrated the absence of drug–polymer interactions and assessed the amorphous state of the drug-CD complex loaded into NPs. Drug release rate from NPs was strongly influenced by the presence and kind of CD used. The percentage released at 24 h varied from 16% (plain drug-loaded NPs) to 50% (drug-βCD-loaded NPs) up to 100% (drug-methylβCD-loaded NPs). This result suggests the possibility of using CD complexation not only to promote, but also to regulate drug release rate from NPs, by selecting the proper type of CD or CD combination.
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