抗冻蛋白
氢键
范德瓦尔斯力
化学
互补性(分子生物学)
防冻剂
疏水效应
受体
配体(生物化学)
生物物理学
结晶学
生物
生物化学
分子
遗传学
有机化学
作者
Zongchao Jia,Peter L. Davies
标识
DOI:10.1016/s0968-0004(01)02028-x
摘要
Antifreeze proteins (AFPs) help organisms to survive below 0 degrees C by inhibiting ice growth. Although AFPs are structurally diverse, they typically present a large proportion of their surface area for binding to ice. Whereas earlier proposed binding mechanisms relied almost entirely on a hydrogen bond match between the AFP and ice, it now seems probable that van der Waals and hydrophobic interactions make a significant contribution to the enthalpy of adsorption. These interactions require intimate surface-surface complementarity between the receptor (AFP) and its ligand (ice).
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